Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity

Frontiers in Immunology

Immunology

Guoqiang Zhong¹  Mingsong Li¹  Shanping Wang¹  Chengcheng He¹  Chuangzhen Lin¹ 

[1] Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China;

关键词: cholesterol-25-hydroxylase;    25-hydroxycholesterol;    inflammatory bowel disease;    intestinal immunity;    mechanism;   

DOI  :  10.3389/fimmu.2023.1241262

 received in 2023-06-16, accepted in 2023-08-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

Inflammatory bowel disease (IBD), a general term encompassing Crohn’s disease (CD) and ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease that can occur in any part of the digestive tract. While the cause of IBD remains unclear, it is acknowledged that the disease has much to do with the dysregulation of intestinal immunity. In the intestinal immune regulatory system, Cholesterol-25-hydroxylase (CH25H) plays an important role in regulating the function of immune cells and lipid metabolism through catalyzing the oxidation of cholesterol into 25-hydroxycholesterol (25-HC). Specifically, CH25H focuses its mechanism of regulating the inflammatory response, signal transduction and cell migration on various types of immune cells by binding to relevant receptors, and the mechanism of regulating lipid metabolism and immune cell function via the transcription factor Sterol Regulator-Binding Protein. Based on this foundation, this article will review the function of CH25H in intestinal immunity, aiming to provide evidence for supporting the discovery of early diagnostic and treatment targets for IBD.

【 授权许可】

Unknown   
Copyright © 2023 Zhong, He, Wang, Lin and Li