Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis

Frontiers in Aging Neuroscience

Aging Neuroscience

Xinyi Yang¹  Huimin Wu¹  Yu Song¹  Shanshan Chen¹  Xingjian Lin¹  Honglin Ge²  Zheng Yan²  Jiu Chen³  Qianqian Yuan⁴  Xuhong Liang⁴ 

[1] Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;Department of Radiology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China;Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China;Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China;Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China;

关键词: activation likelihood estimation;    amplitude of low-frequency fluctuation;    frontoparietal network;    functional connectivity;    mild cognitive impairment;    regional homogeneity;   

DOI  :  10.3389/fnagi.2023.1165908

 received in 2023-02-14, accepted in 2023-05-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundMild cognitive impairment (MCI) depicts a transitory phase between healthy elderly and the onset of Alzheimer's disease (AD) with worsening cognitive impairment. Some functional MRI (fMRI) research indicated that the frontoparietal network (FPN) could be an essential part of the pathophysiological mechanism of MCI. However, damaged FPN regions were not consistently reported, especially their interactions with other brain networks. We assessed the fMRI-specific anomalies of the FPN in MCI by analyzing brain regions with functional alterations.MethodsPubMed, Embase, and Web of Science were searched to screen neuroimaging studies exploring brain function alterations in the FPN in MCI using fMRI-related indexes, including the amplitude of low-frequency fluctuation, regional homogeneity, and functional connectivity. We integrated distinctive coordinates by activating likelihood estimation, visualizing abnormal functional regions, and concluding functional alterations of the FPN.ResultsWe selected 29 studies and found specific changes in some brain regions of the FPN. These included the bilateral dorsolateral prefrontal cortex, insula, precuneus cortex, anterior cingulate cortex, inferior parietal lobule, middle temporal gyrus, superior frontal gyrus, and parahippocampal gyrus. Any abnormal alterations in these regions depicted interactions between the FPN and other networks.ConclusionThe study demonstrates specific fMRI neuroimaging alterations in brain regions of the FPN in MCI patients. This could provide a new perspective on identifying early-stage patients with targeted treatment programs.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432042, identifier: CRD42023432042.

【 授权许可】

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Copyright © 2023 Yang, Wu, Song, Chen, Ge, Yan, Yuan, Liang, Lin and Chen.