SARS-CoV-2 and the host-immune response

Frontiers in Immunology

Immunology

Mariana Gerschenson¹  David P. Maison¹  Youping Deng² 

[1] Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States;Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States;

关键词: COVID-19;    immune response;    innate immunity;    adaptive immunity;    viral immune evasion;   

DOI  :  10.3389/fimmu.2023.1195871

 received in 2023-03-29, accepted in 2023-06-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

The SARS-CoV-2 pandemic and the COVID-19 disease have affected everyone globally, leading to one of recorded history’s most significant research surges. As our knowledge evolves, our approaches to the virus and treatments must also evolve. The evaluation of future research approaches to SARS-CoV-2 will necessitate reviewing the host immune response and viral antagonism of that response. This review provides an overview of the current knowledge on SARS-CoV-2 by summarizing the virus and human response. The focuses are on the viral genome, replication cycle, host immune activation, response, signaling, and antagonism. To effectively fight the pandemic, efforts must focus on the current state of research to help develop treatments and prepare for future outbreaks.

【 授权许可】

Unknown   
Copyright © 2023 Maison, Deng and Gerschenson