Smaller baseline subcortical infarct volume predicts good outcomes in patients with a large core in early acute ischemic stroke after endovascular treatment

Frontiers in Neuroscience

Neuroscience

Yu Hang¹  Sheng Liu¹  Zhenyu Jia¹  Yuezhou Cao¹  Linbo Zhao¹  Yiming Gu²  Ying Liu³  Yasuo Ding⁴ 

[1] Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;Department of Interventional Radiology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China;Department of Neurology, Taizhou People’s Hospital, Taizhou, China;Department of Neurosurgery, Taizhou People’s Hospital, Taizhou, China;

关键词: acute ischemic stroke;    endovascular thrombectomy;    infarct volume;    predictor;    good outcomes;   

DOI  :  10.3389/fnins.2023.1063478

 received in 2022-10-07, accepted in 2023-01-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPatients with acute ischemic stroke (AIS) and a large core may benefit from endovascular treatment (EVT) in the early time window.PurposeTo examine the prognostic factors for good outcomes in patients with a large core (70–130 ml) after EVT.Materials and methodsWe retrospectively reviewed 40 patients who met the criteria from October 2019 to April 2021. Based on the modified Rankin Score (mRS) at 90 days, the patients were divided into a good outcome group (mRS 0–2) and a poor outcome group (mRS 3–6). Baseline and procedural characteristics were collected for unilateral and multivariate regression analyses to explore the factors that influence good outcomes. In particular, the infarct territories were quantified as subcortical infarct volume (SIV) and cortical infarct volume (CIV).ResultsOf the 40 patients included, good outcomes were observed in 11 (27.5%) patients. Younger age, smaller SIV and larger mismatch volume were noted in the good outcome group than in the poor outcome group (all P < 0.05). Multivariate logistic regression analysis showed that only a smaller SIV [odds ratio (OR) 0.801; 95% CI 0.644–0.996; P = 0.046] was an independent predictor for good outcomes. The receiver operating characteristic curve indicated a moderate value of SIV for predicting good outcomes, with an area under the receiver operating characteristic curve of 0.735 (95% CI 0.572–0.862; P = 0.007).ConclusionSubcortical infarct volume was a potential useful predictor of good outcomes in patients with a large core after EVT in the early time window.

【 授权许可】

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Copyright © 2023 Gu, Ding, Hang, Cao, Jia, Zhao, Liu and Liu.