Clinical advancement of precision theranostics in prostate cancer

Frontiers in Oncology

Oncology

Yongxiang Tang¹  Zhihui Fang²  Hong Zhao³  Kai Liu⁴  Yue Tan⁵ 

[1] Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China;Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China;Key Laboratory of Biological Nanotechnology of National Health Commission, Xiangya Hospital, Central South University, Changsha, Hunan, China;Department of Systems Medicine and Bioengineering, Houston Methodist Neal Cancer Center, Weill Cornell Medicine, Houston TX, United States;Department of Systems Medicine and Bioengineering, Houston Methodist Neal Cancer Center, Weill Cornell Medicine, Houston TX, United States;Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China;Hengyang Medical College, University of South China, Hengyang, Hunan, China;Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China;

关键词: theranostics;    imaging;    prostate cancer;    radiotracer;    PET/CT;   

DOI  :  10.3389/fonc.2023.1072510

 received in 2022-10-17, accepted in 2023-01-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Theranostic approaches with positron emission tomography/computed tomography (PET/CT) or PET/magnetic resonance imaging (PET/MRI) molecular imaging probes are being implemented clinically in prostate cancer (PCa) diagnosis and imaging-guided precision surgery. This review article provides a comprehensive summary of the rapidly expanding list of molecular imaging probes in this field, including their applications in early diagnosis of primary prostate lesions; detection of lymph node, skeletal and visceral metastases in biochemical relapsed patients; and intraoperative guidance for tumor margin detection and nerve preservation. Although each imaging probe shows preferred efficacy in some applications and limitations in others, the exploration and research efforts in this field will eventually lead to improved precision theranostics of PCa.

【 授权许可】

Unknown   
Copyright © 2023 Tan, Fang, Tang, Liu and Zhao