Molecular Imaging Insights into Neurodegeneration: Focus on α-Synuclein Radiotracers

Journal of Nuclear Medicine

Anna Cartier¹  Maliha Shah¹  Ram Bhatt¹  Ana M. Catafau¹  John Seibyl¹ 

关键词: α-synuclein;    radiotracer;    imaging;    neurodegeneration;    Parkinson’s;   

DOI  :  10.2967/jnumed.113.136515

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Neurodegenerative diseases characterized by the presence of α-synucleina hallmark of pathologic inclusions termed Lewy bodiesinclude Parkinson’s disease, dementia with Lewy bodies, and multiple-system atrophy. Although motor symptoms are related to the altered presynaptic dopaminergic function in these diseases, the appearance of α-synuclein inclusions precedes the involvement of the nigrostriatal dopaminergic pathway. Hence, the most accurate and earliest definition of premotor Parkinson’s disease ought to rely on imaging α-synuclein rather than dopaminergic changes. Moreover, dopaminergic imaging has been controversial in monitoring the effects of investigational disease-modifying drugs. For these clinical trials, intense interest in longitudinally imaging α-synuclein as the primary pathologic process has led to efforts toward developing a suitable radiotracer for this key protein. An overview of the present α-synuclein radiotracer development scenario is presented here.

【 授权许可】

Unknown