The role of the microbiota-gut-brain axis and intestinal microbiome dysregulation in Parkinson’s disease

Frontiers in Neurology

Neurology

Ling-bing Meng¹  Ling Tu²  Qing Li²  Li-jun Chen²  Qi Zhou²  Jin-long Yu²  Yuan Zeng²  Xin Liao²  Xia Shi²  Qiao-ying Yuan² 

[1] Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China;Department of Nutrition, Southwest Hospital, Third Military Medical University (Army Medical University), The First Affiliated Hospital of PLA Army Medical University, Chongqing, China;

关键词: Parkinson’s disease;    microbiota-gut-brain axis;    intestinal microbiome dysregulation;    inflammation;    gastrointestinal dysfunction;   

DOI  :  10.3389/fneur.2023.1185375

 received in 2023-03-13, accepted in 2023-04-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Parkinson’s disease (PD) is a complex progressive neurodegenerative disease associated with aging. Its main pathological feature is the degeneration and loss of dopaminergic neurons related to the misfolding and aggregation of α-synuclein. The pathogenesis of PD has not yet been fully elucidated, and its occurrence and development process are closely related to the microbiota-gut-brain axis. Dysregulation of intestinal microbiota may promote the damage of the intestinal epithelial barrier, intestinal inflammation, and the upward diffusion of phosphorylated α-synuclein from the enteric nervous system (ENS) to the brain in susceptible individuals and further lead to gastrointestinal dysfunction, neuroinflammation, and neurodegeneration of the central nervous system (CNS) through the disordered microbiota-gut-brain axis. The present review aimed to summarize recent advancements in studies focusing on the role of the microbiota-gut-brain axis in the pathogenesis of PD, especially the mechanism of intestinal microbiome dysregulation, intestinal inflammation, and gastrointestinal dysfunction in PD. Maintaining or restoring homeostasis in the gut microenvironment by targeting the gut microbiome may provide future direction for the development of new biomarkers for early diagnosis of PD and therapeutic strategies to slow disease progression.

【 授权许可】

Unknown   
Copyright © 2023 Li, Meng, Chen, Shi, Tu, Zhou, Yu, Liao, Zeng and Yuan.