Differences in subthalamic oscillatory activity in the two hemispheres associated with severity of Parkinson’s disease

Frontiers in Aging Neuroscience

Neuroscience

Xuemin Zhao¹  Yuqing Zhang¹  Yunpeng Wang¹  Yi Wen¹  Yongjie Li¹  Jiping Li¹  Yongsheng Hu¹  Jianyu Li¹  Ping Zhuang²  Mark Hallett³ 

[1] Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University and Key Laboratory of Neurodegenerative Disease, Ministry of Education (Capital Medical University), Beijing, China;Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University and Key Laboratory of Neurodegenerative Disease, Ministry of Education (Capital Medical University), Beijing, China;Center for Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China;National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States;

关键词: Parkinson’s disease;    asymmetry;    subthalamic nucleus;    oscillation;    firing rate;    microelectrode recording;   

DOI  :  10.3389/fnagi.2023.1185348

 received in 2023-03-13, accepted in 2023-08-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundIt is well known that motor features of Parkinson’s disease (PD) commonly begin on one side of the body and extend to the other side with disease progression. The onset side generally remains more severely affected over the course of the disease. However, the pathophysiology underlying the asymmetry of motor manifestations remains unclear. The purpose of the present study is to examine whether alterations in neuronal activity in the subthalamic nucleus (STN) associate with PD severity.MethodsMicroelectrode recording was performed in the STN during targeting for 30 patients in the treatment of deep brain stimulation. The mean spontaneous firing rate (MSFR), power density spectral analysis, and correlations were calculated. Characteristics of subthalamic oscillatory activity were compared between two hemispheres. UPDRS III scores during “Off” and “On” states were obtained for the body side of initial symptoms (BSIS) and the body side of extended symptoms (BSES).ResultsThere were significant differences of MSFR (41.3 ± 11.0 Hz vs 35.2 ± 10.0 Hz) and percentage of ß frequency oscillatory neurons (51.3% vs 34.9%) between BSIS and BSES. The percentage of ß frequency oscillatory neurons correlated with the bradykinesia/rigidity scores for both sides (p < 0.05). In contrast, the percentage of tremor frequency oscillatory neurons was significantly higher in the BSES than that in the BSIS. In particular, these neurons only correlated with the tremor scores of the BSES (p < 0.05).ConclusionThe results suggest that increased neuronal firing rate and ß frequency oscillatory neurons in the STN are associated with contralateral side motor severity and its progression. Tremor frequency oscillatory neurons are less observed in the STN of the BSIS suggesting that ß oscillatory activity dominates and tremor frequency oscillatory activity reciprocally declines.

【 授权许可】

Unknown   
Copyright © 2023 Zhao, Zhuang, Hallett, Zhang, Li, Wen, Li, Wang, Hu and Li.