期刊论文详细信息
Frontiers in Endocrinology
High density lipoprotein-associated proteins in non-obese women with and without polycystic ovary syndrome
Endocrinology
Thozhukat Sathyapalan1  Tannaz Jamialahmadi2  Amirhossein Sahebkar3  Željko Reiner4  Alexandra E. Butler5  Abu Saleh Md Moin5  Stephen L. Atkin5 
[1] Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Hull, United Kingdom;Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;School of Medicine, The University of Western Australia, Perth, WA, Australia;Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia;Research Department, Royal College of Surgeons in Ireland Bahrain, Adliya, Bahrain;
关键词: polycystic ovary syndrome;    lipids;    HDL;    LDL;    dyslipidemia;   
DOI  :  10.3389/fendo.2023.1117761
 received in 2022-12-06, accepted in 2023-04-03,  发布年份 2023
来源: Frontiers
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【 摘 要 】

IntroductionDyslipidemia frequently occurs in women with polycystic ovary syndrome (PCOS), but it is unclear whether dyslipidemia is due to obesity and insulin resistance (IR) or is inherent to PCOS. To address this, proteomic analysis of proteins important in lipid metabolism, particularly for high-density lipoprotein cholesterol (HDL-C), was performed in non-obese, non-insulin resistant PCOS women compared to matched controls.MethodsWeight and aged-matched non-obese subjects with PCOS (n=24) and without IR were compared with control women (n=24). 19 proteins were measured by Somalogic proteomic analysis: alpha-1-antichymotrypsin, alpha-1-antitrypsin, apolipoproteins A-1, B, D, E, E2, E3, E4, L1, M, clusterin, complement C3, hemopexin, heparin cofactor-II (HCFII), kininogen-1, serum amyloid A-1, amyloid beta A-4 and paraoxonase-1.ResultsWomen with PCOS had a higher free androgen index (FAI) (p<0.001) and anti-Mullerian hormone (AMH) (p<0.001), but IR and C-reactive protein (CRP), a marker of inflammation, did not differ from controls (p>0.05). The triglyceride:HDL-cholesterol ratio was elevated (p=0.03) in PCOS. Alpha-1-antitrypsin levels were lower (p<0.05) and complement C3 levels were higher (p=0.001) in PCOS. C3 correlated with body mass index (BMI) (r=0.59, p=0.001), IR (r=0.63, p=0.0005) and CRP (r=0.42, p=0.04) in women with PCOS, though no correlations of these parameters with alpha-1-antitrypsin were found. Total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and levels of the other 17 lipoprotein metabolism-associated proteins did not differ between the two groups (p>0.05). However, in PCOS, alpha-1-antichymotrypsin correlated negatively with BMI (r=-0.40, p<0.04) and HOMA-IR (r=-0.42, p<0.03), apoM correlated positively with CRP (r=0.36, p<0.04) and HCFII correlated negatively with BMI (r=-0.34, p<0.04).ConclusionIn PCOS subjects, when obesity, IR and inflammation confounders were absent, alpha-1-antitrypsin was lower and complement C3 was higher than in non-PCOS women, suggesting increased cardiovascular risk; however, subsequent obesity related IR/inflammation likely stimulates other HDL-associated protein abnormalities, thus increasing cardiovascular risk further.

【 授权许可】

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Copyright © 2023 Butler, Moin, Reiner, Sathyapalan, Jamialahmadi, Sahebkar and Atkin

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