Changes in macrophage function modulated by the lipid environment:

Innate Immunity

Michael RWilliams¹ 

关键词: Macrophages;    lipids;    cholesterol;    inflammation;    HDL;    LDL;    receptors;   

DOI  :  10.1177/1753425916633886

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Macrophages (Mφs) play a critical role in the defense against pathogens, orchestrating the inflammatory response during injury and maintaining tissue homeostasis. During these processes, macrophages encounter a variety of environmental conditions that are likely to change their gene expression pattern, which modulates their function. In this study, we found that murine Mφs displayed two different subpopulations characterized by differences in morphologies, expression of surface markers and phagocytic capacity under non-stimulated conditions. These two subpopulations could be recapitulated by changes in the culture conditions. Thus, Mφs grown in suspension in the presence of serum were highly phagocytic, whereas subtraction of serum resulted in rapid attachment and reduced phagocytic activity. The difference in phagocytosis between these subpopulations was correlated with the expression levels of FcγR. These two cell subpopulations also differed in their responses to LPS and the expression of surface marke...

【 授权许可】

CC BY