Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Blessy Joseph¹  Nur Izzah Md Fadilah²  Zawani Mazlan²  Manira Maarof²  Shaima Maliha Riha²  Mh Busra Fauzi²  Antonella Motta³  Adzim Poh Yuen Wen⁴  Sabu Thomas⁵  Looi Qi Hao⁶ 

[1] Business Innovation and Incubation Centre, Mahatma Gandhi University, Kottayam, Kerala, India;Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia;Department of Industrial Engineering, University of Trento, Trento, Italy;Department of Surgery, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia;International and Inter University Centre for Nanosciences and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala, India;My Cytohealth Sdn Bhd Kuala Lumpur, Kuala Lumpur, Malaysia;

关键词: multifunctional bioscaffolds;    skin substitutes;    biomaterials;    wound healing;    skin tissue engineering;   

DOI  :  10.3389/fbioe.2023.1160577

 received in 2023-02-07, accepted in 2023-05-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

Skin tissue engineering possesses great promise in providing successful wound injury and tissue loss treatments that current methods cannot treat or achieve a satisfactory clinical outcome. A major field direction is exploring bioscaffolds with multifunctional properties to enhance biological performance and expedite complex skin tissue regeneration. Multifunctional bioscaffolds are three-dimensional (3D) constructs manufactured from natural and synthetic biomaterials using cutting-edge tissue fabrication techniques incorporated with cells, growth factors, secretomes, antibacterial compounds, and bioactive molecules. It offers a physical, chemical, and biological environment with a biomimetic framework to direct cells toward higher-order tissue regeneration during wound healing. Multifunctional bioscaffolds are a promising possibility for skin regeneration because of the variety of structures they provide and the capacity to customise the chemistry of their surfaces, which allows for the regulated distribution of bioactive chemicals or cells. Meanwhile, the current gap is through advanced fabrication techniques such as computational designing, electrospinning, and 3D bioprinting to fabricate multifunctional scaffolds with long-term safety. This review stipulates the wound healing processes used by commercially available engineered skin replacements (ESS), highlighting the demand for a multifunctional, and next-generation ESS replacement as the goals and significance study in tissue engineering and regenerative medicine (TERM). This work also scrutinise the use of multifunctional bioscaffolds in wound healing applications, demonstrating successful biological performance in the in vitro and in vivo animal models. Further, we also provided a comprehensive review in requiring new viewpoints and technological innovations for the clinical application of multifunctional bioscaffolds for wound healing that have been found in the literature in the last 5 years.

【 授权许可】

Unknown   
Copyright © 2023 Fadilah, Riha, Mazlan, Wen, Hao, Joseph, Maarof, Thomas, Motta and Fauzi.

【 图 表 】

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