Cell-targeted vaccines: implications for adaptive immunity

Frontiers in Immunology

Immunology

Peter Deak¹  Nakisha S. Rutledge²  Trevor Ung²  Aaron P. Esser-Kahn²  Adam M. Weiss² 

[1] Chemical and Biological Engineering Department, Drexel University, Philadelphia, PA, United States;Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, United States;

关键词: vaccine;    innate immunity;    targeted vaccines;    cell targeting;    adaptive immunity;   

DOI  :  10.3389/fimmu.2023.1221008

 received in 2023-05-11, accepted in 2023-07-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

Recent advancements in immunology and chemistry have facilitated advancements in targeted vaccine technology. Targeting specific cell types, tissue locations, or receptors can allow for modulation of the adaptive immune response to vaccines. This review provides an overview of cellular targets of vaccines, suggests methods of targeting and downstream effects on immune responses, and summarizes general trends in the literature. Understanding the relationships between vaccine targets and subsequent adaptive immune responses is critical for effective vaccine design. This knowledge could facilitate design of more effective, disease-specialized vaccines.

【 授权许可】

Unknown   
Copyright © 2023 Ung, Rutledge, Weiss, Esser-Kahn and Deak