Surface modification improving the biological activity and osteogenic ability of 3D printing porous dental implants

Frontiers in Materials

Materials

Jingjing Gao¹  Zhihong Dong¹  Yun He¹  Shuai Long¹  Zugan Qin¹  Lijia Cheng²  Zheng Shi³ 

[1]School of Basic Medical Sciences, Clinical Medical College, Affiliated Hospital, Mechanical Engineering College of Chengdu University, Chengdu, China

[2][e-mail]

[3]null

关键词: 3D printing;    titanium alloy;    pore structure;    dental implants;    surface modification;   

DOI  :  10.3389/fmats.2023.1183902

 received in 2023-03-23, accepted in 2023-05-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

Objective: To explore the mechanical properties, biological activity, and osteogenic ability of 3D printed TC4 titanium (Ti) alloy dental implants treated with surface modification.Methods: Dental implants with 30% porosity were manufactured using selective laser melting (SLM) technology (group 3D), while traditional numerically-controlled machine tools (CNC) were used to manufacture implants without porosity (group SL). The implants were then surface modified through sandblasting and acid etching (groups 3DA1 and SLA1), and then alkali etching (groups 3DA2 and SLA2). The physicochemical properties of the implants were measured using a Vickers hardness instrument, scanning electron microscope (SEM), X-ray diffraction (XRD), energy dispersive spectrometer (EDS), and profilograph before and after surface modification. Next, the biocompatibility, bioactivity, and osteogenic ability of the implants were evaluated using apatite deposition experiments, alkaline phosphatase (ALP) activity, and semiquantitative analysis of extracellular matrix mineralization.Results: There were significant differences in morphology, geometric accuracy, mechanical properties, surface roughness, and hydrophilicity between groups 3D and SL. Furthermore, surface modification improved the physicochemical properties of the porous implants. Implants with sandblasting, acid etching, and alkali etching demonstrated better biocompatibility, bioactivity, and osteogenic ability than implants without surface modification in both groups 3D and SL. Additionally, the implants of groups 3D have higher bioactivity than that of groups SL.Conclusion: Surface modification and the macroporous structure of implants can improve their bioactivity and osteogenic ability, enhancing the application of Ti alloy dental implants.

【 授权许可】

Unknown   
Copyright © 2023 Qin, He, Gao, Dong, Long, Cheng and Shi.