The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trial

Frontiers in Psychiatry

Psychiatry

Sangsang Xiong¹  Xiaomei Shao¹  Nisang Chen¹  Xiaoting Wu¹  Mingqi Tu¹  Junyan Jin¹  Siying Qu¹  Zhijian Cao²  Maosheng Xu²  Jiajia Yang²  Jianqiao Fang³  Hantong Hu³  Yinyan Ge³  Shuangyi Pei³ 

[1] Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases, The Third Clinical Medical College, Zhejiang Chinese Medical University,, Hangzhou, China;The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China;The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China;The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China;

关键词: major depressive disorder;    intradermal acupuncture;    cerebral mechanism;    magnetic resonance imaging;    magnetic resonance spectroscopy;    selective serotonin reuptake inhibitors;   

DOI  :  10.3389/fpsyt.2023.1181947

 received in 2023-03-08, accepted in 2023-04-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundMajor depressive disorder (MDD) has emerged as the fifth leading cause of years lived with disability, with a high prevalent, affecting nearly 4% of the global population. While available evidence suggests that intradermal acupuncture may enhance the effectiveness of antidepressants, whether its efficacy is a specific therapeutic effect or a placebo effect has not been reported. Moreover, the cerebral mechanism of intradermal acupuncture as a superficial acupuncture (usually subcutaneous needling to a depth of 1–2 mm) for MDD remains unclear.MethodsA total of 120 participants with MDD will be enrolled and randomized to the waiting list group, sham intradermal acupuncture group and active intradermal acupuncture group. All 3 groups will receive a 6-week intervention and a 4-week follow-up. The primary outcome will be measured by the Hamilton Depression Rating Scale-17 and the secondary outcome measures will be the Self-Rating depression scale and Pittsburgh sleep quality index. Assessments will be conducted at baseline, 3 weeks, 6 weeks, and during the follow-up period. In addition, 20 eligible participants in each group will be randomly selected to undergo head magnetic resonance imaging before and after the intervention to explore the effects of intradermal acupuncture on brain activity in MDD patients.DiscussionIf the intradermal acupuncture is beneficial, it is promising to be included in the routine treatment of MDD.Clinical Trial RegistrationClinicaltrials.gov, NCT05720637.

【 授权许可】

Unknown   
Copyright © 2023 Wu, Tu, Chen, Yang, Jin, Qu, Xiong, Cao, Xu, Pei, Hu, Ge, Fang and Shao.

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