Increased risk of new-onset diabetes in patients with COVID-19: a systematic review and meta-analysis

Frontiers in Public Health

Public Health

Nanyang Liu¹  Lanye He¹  Zhenzhen Wang²  Jiajun Li³  Han Zhang³  Yapeng Li⁴ 

[1] Department of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China;Department of Orthopaedic Surgery, Luoyang First People's Hospital, Luoyang, China;Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China;Rehabilitation Therapy Center, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, China;

关键词: COVID-19;    severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);    new-onset;    secondary diabetes;    hyperglycemia;   

DOI  :  10.3389/fpubh.2023.1170156

 received in 2023-02-20, accepted in 2023-05-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThere is growing evidence that patients with COVID-19 are at increased risk of new-onset diabetes. The limited preliminary studies do not provide strong evidence. To assess the association of the SARS-CoV-2 virus with new-onset diabetes and to characterize the population.MethodsSearch PubMed, Embase, Cochrane Library, and Web of Science electronic databases for a limited period from December 2019 to July 2022. Two independent reviewers conducted a thorough review of eligible articles and extracted relevant information. Pooled proportions, risk ratios (RR), and 95% confidence intervals (95% CI) indicated the incidence and risk ratios of events.ResultsThe incidence of new-onset diabetes and hyperglycemia in patients with COVID-19 was 5% (P < 0.001) (3 and 30% for new-onset diabetes and hyperglycemia, respectively), with age, ethnicity, time of diagnosis, and study type all having an impact on the incidence (P < 0.05). New-onset diabetes and hyperglycemia were 1.75 times higher in COVID-19 patients than in non-COVID-19 patients. In new-onset diabetes and hyperglycemia population, the percentage of men is 60% (40% for women), with a mortality rate of 17%. The proportion of new-onset diabetes and hyperglycemia after infection with COVID-19 was 25% in men and 14% in women.ConclusionsThe incidence and relative risk of new-onset diabetes and hyperglycemia are elevated after COVID-19 infection, especially in the early COVID-19 and male populations.Systemic review registrationPROSPERO registration no.: CRD42022382989 https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=382989.

【 授权许可】

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Copyright © 2023 Li, Li, Wang, Liu, He and Zhang.