Frontiers in Immunology | |
The role of mesenchymal stem cell-derived EVs in diabetic wound healing | |
Immunology | |
Junhui Zhang1  Hongmei Li2  Min Jiang3  Ze Zhang3  Xupin Jiang3  Can Zhang3  Chao Wu3  Jiaping Zhang3  Jiongyu Hu4  | |
[1] Department of Geriatic Oncology, Department of Palliative Care, Department of Clinical Nutrition, Chongqing University Cancer Hospital, Chongqing, China;Endocrinology Department, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China;Department of Oncology and Southwest Cancer Center, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China;Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China;Endocrinology Department, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China; | |
关键词: angiogenesis; mesenchymal stem cells; exosomes; diabetes wound; extracellular vesicles; | |
DOI : 10.3389/fimmu.2023.1136098 | |
received in 2023-01-02, accepted in 2023-02-09, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Diabetic foot is one of the most common complications of diabetes, requiring repeated surgical interventions and leading to amputation. In the absence of effective drugs, new treatments need to be explored. Previous studies have found that stem cell transplantation can promote the healing of chronic diabetic wounds. However, safety issues have limited the clinical application of this technique. Recently, the performance of mesenchymal stem cells after transplantation has been increasingly attributed to their production of exocrine functional derivatives such as extracellular vesicles (EVs), cytokines, and cell-conditioned media. EVs contain a variety of cellular molecules, including RNA, DNA and proteins, which facilitate the exchange of information between cells. EVs have several advantages over parental stem cells, including a high safety profile, no immune response, fewer ethical concerns, and a reduced likelihood of embolism formation and carcinogenesis. In this paper, we summarize the current knowledge of mesenchymal stem cell-derived EVs in accelerating diabetic wound healing, as well as their potential clinic applications.
【 授权许可】
Unknown
Copyright © 2023 Jiang, Jiang, Li, Zhang, Zhang, Wu, Zhang, Hu and Zhang
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202310103590416ZK.pdf | 1638KB | download |