The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Frontiers in Immunology

Immunology

Junhui Zhang¹  Hongmei Li²  Min Jiang³  Ze Zhang³  Xupin Jiang³  Can Zhang³  Chao Wu³  Jiaping Zhang³  Jiongyu Hu⁴ 

[1] Department of Geriatic Oncology, Department of Palliative Care, Department of Clinical Nutrition, Chongqing University Cancer Hospital, Chongqing, China;Endocrinology Department, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China;Department of Oncology and Southwest Cancer Center, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China;Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China;Endocrinology Department, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China;

关键词: angiogenesis;    mesenchymal stem cells;    exosomes;    diabetes wound;    extracellular vesicles;   

DOI  :  10.3389/fimmu.2023.1136098

 received in 2023-01-02, accepted in 2023-02-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Diabetic foot is one of the most common complications of diabetes, requiring repeated surgical interventions and leading to amputation. In the absence of effective drugs, new treatments need to be explored. Previous studies have found that stem cell transplantation can promote the healing of chronic diabetic wounds. However, safety issues have limited the clinical application of this technique. Recently, the performance of mesenchymal stem cells after transplantation has been increasingly attributed to their production of exocrine functional derivatives such as extracellular vesicles (EVs), cytokines, and cell-conditioned media. EVs contain a variety of cellular molecules, including RNA, DNA and proteins, which facilitate the exchange of information between cells. EVs have several advantages over parental stem cells, including a high safety profile, no immune response, fewer ethical concerns, and a reduced likelihood of embolism formation and carcinogenesis. In this paper, we summarize the current knowledge of mesenchymal stem cell-derived EVs in accelerating diabetic wound healing, as well as their potential clinic applications.

【 授权许可】

Unknown   
Copyright © 2023 Jiang, Jiang, Li, Zhang, Zhang, Wu, Zhang, Hu and Zhang