Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus

Frontiers in Immunology

Immunology

Stefanie Samietz¹  Hans J. Grabe²  Clemens Cammann³  Cedric Mahncke³  Christian Kohler³  Stephan B. Felix⁴  Marcus Dörr⁴  Henry Völzke⁵  Nele Friedrich⁶  Matthias Nauck⁶  Frieder Schmiedeke⁷  Silva Holtfreter⁷  Barbara M. Bröker⁷  Georg Homuth⁸  Stephan Michalik⁸  Tanja C. Meyer⁸  Uwe Völker⁹  Stefan Weiss⁹ 

[1] Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University Medicine Greifswald, Greifswald, Germany;Department of Psychatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany;Friedrich Loeffler Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany;German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany;Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany;German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany;Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany;German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany;Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany;Institute of Immunology, University Medicine Greifswald, Greifswald, Germany;Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany;Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany;German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany;

关键词: Staphylococcus aureus;    toxic shock syndrome;    TSST-1;    superantigen;    GWA;    HLA;    MHC;    antibody;   

DOI  :  10.3389/fimmu.2023.1229562

 received in 2023-05-26, accepted in 2023-07-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies. To identify determinants of the anti-TSST-1 antibody response, we examined 976 participants of the German population-based epidemiological Study of Health in Pomerania (SHIP-TREND-0). We measured anti-TSST-1 antibody levels, analyzed the colonization with TSST-1-encoding S. aureus strains, and performed a genome-wide association analysis of genetic risk factors. TSST-1-specific serum IgG levels varied over a range of 4.2 logs and were elevated by a factor of 12.3 upon nasal colonization with TSST-1-encoding S. aureus. Moreover, the anti-TSST-1 antibody levels were strongly associated with HLA class II gene loci. HLA-DRB1*03:01 and HLA-DQB1*02:01 were positively, and HLA-DRB1*01:01 as well as HLA-DQB1*05:01 negatively associated with the anti-TSST-1 antibody levels. Thus, both toxin exposure and HLA alleles affect the human antibody response to TSST-1.

【 授权许可】

Unknown   
Copyright © 2023 Weiss, Holtfreter, Meyer, Schmiedeke, Cammann, Dörr, Felix, Grabe, Homuth, Kohler, Mahncke, Michalik, Nauck, Friedrich, Samietz, Völzke, Völker and Bröker