The role of WNT and IL-1 signaling in osteoarthritis: therapeutic implications for platelet-rich plasma therapy

Frontiers in Aging

Aging

Nicola Rani¹  Cristiano Sconza²  Berardo Di Matteo³  Angela Ceribelli⁴  Antonio Tonutti⁴  Cristina Sobacchi⁵  Veronica Marrella⁵  Valentina Granata⁵  Rita Ragusa⁶ 

[1] Conservative Orthopaedic Surgery and Innovative Techniques, Rizzoli Orthopaedic Institute, Bologna, Italy;Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Department of Rehabilitation and Functional Recovery, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Rozzano, Milan, Italy;Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Division of Orthopedics, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Rozzano, Italy;Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Rheumatology and Clinical Immunology, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Rozzano, Italy;Human Genome and Biomedical Technologies Unit, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Rozzano, Italy;Milan Unit, National Research Council—Institute for Genetic and Biomedical Research (CNR-IRGB), Milan, Italy;Rheumatology and Clinical Immunology, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Rozzano, Italy;

关键词: osteoarthritis;    inflammatory pathways;    platelet-rich-plasma;    autologous therapy;    immunology;   

DOI  :  10.3389/fragi.2023.1201019

 received in 2023-04-05, accepted in 2023-05-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

Different from inflammatory arthritis, where biologicals and targeted synthetic molecules have revolutionized the disease course, no drug has demonstrated a disease modifying activity in osteoarthritis, which remains one of the most common causes of disability and chronic pain worldwide. The pharmacological therapy of osteoarthritis is mainly directed towards symptom and pain relief, and joint replacement is still the only curative strategy. Elucidating the disease pathophysiology is essential to understand which mechanisms can be targeted by innovative therapies. It has extensively been demonstrated that aberrant WNT and IL-1 signaling pathways are responsible for cartilage degeneration, impaired chondrocyte metabolism and differentiation, increased extracellular matrix degradation, and altered subchondral bone homeostasis. Platelet-rich plasma is an autologous blood derivative containing a concentration of platelets that is much higher than the whole blood counterpart and has shown promising results in the treatment of early knee osteoarthritis. Among the proposed mechanisms, the modulation of WNT and IL-1 pathways is of paramount importance and is herein reviewed in light of the proposed regenerative approaches.

【 授权许可】

Unknown   
Copyright © 2023 Tonutti, Granata, Marrella, Sobacchi, Ragusa, Sconza, Rani, Di Matteo and Ceribelli.

【 图 表 】

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