m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

Frontiers in Oncology

Oncology

Shaohua Chen¹  Nanfang Qu²  Shuaijie Wang³  Yuzhong Yang³  Xiaohan Jiang³  Xiang Zheng³  Xuemei Zhang⁴  Ziyao Jin⁵ 

[1] Department of Breast and Thyroid Surgery, Liuzhou People’s Hospital Affiliated to Guangxi Medical University, Liuzhou, China;Department of Gastroenterology, Affiliated Hospital of Guilin Medical University, Guilin, China;Department of Pathology, Affiliated Hospital of Guilin Medical University, Guilin, China;Department of Pathology, Liuzhou People’s Hospital Affiliated to Guangxi Medical University, Liuzhou, China;Key Laboratory of Oral Biomedical Research of Zhejiang Province, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China;

关键词: colorectal cancer;    N6-methyladenosine;    RNA modification;    proliferation;    tumorigenesis;   

DOI  :  10.3389/fonc.2023.1162300

 received in 2023-02-09, accepted in 2023-03-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism, including translocation, mRNA stability or decay, pre-mRNA splicing, and lncRNA processing. Numerous studies have shown that m6A modification is involved in the development of various cancers. This review aims to summarize the significant role of m6A modification in the proliferation and tumorigenesis of CRC, as well as the potential of modulating m6A modification for tumor treatment. These findings may offer new therapeutic strategies for clinical implementation of m6A modification in CRC in the near future.

【 授权许可】

Unknown   
Copyright © 2023 Jiang, Jin, Yang, Zheng, Chen, Wang, Zhang and Qu