Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memory

Frontiers in Systems Neuroscience

Neuroscience

Marta Miquel¹  Ignasi Melchor-Eixea²  Aitor Sanchez-Hernandez²  Julian Guarque-Chabrera²  Raúl Pastor²  Patricia Ibáñez-Marín² 

[1] null;Área de Psicobiología, Facultat de Ciències de la Salut, Universitat Jaume I, Castellón de la Plana, Spain;

关键词: cerebellum;    drug addiction;    drug memory;    cocaine;    DREADDs;   

DOI  :  10.3389/fnsys.2023.1154014

 received in 2023-01-30, accepted in 2023-05-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

Substance Use Disorder (SUD) involves emotional, cognitive, and motivational dysfunction. Long-lasting molecular and structural changes in brain regions functionally and anatomically linked to the cerebellum, such as the prefrontal cortex, amygdala, hippocampus, basal ganglia, and ventral tegmental area, are characteristic of SUD. Direct and indirect reciprocal connectivity between the cerebellum and these brain regions can explain cerebellar roles in Pavlovian and reinforcement learning, fear memory, and executive functions. It is increasingly clear that the cerebellum modulates brain functions altered in SUD and other neuropsychiatric disorders that exhibit comorbidity with SUD. In the present manuscript, we review and discuss this evidence and present new research exploring the role of the cerebellum in cocaine-induced conditioned memory using chemogenetic tools (designer receptor exclusively activated by designer drug, DREADDs). Our preliminary data showed that inactivation of a region that includes the interposed and lateral deep cerebellar nuclei reduces the facilitating effect of a posterior vermis lesion on cocaine-induced preference conditioning. These findings support our previous research and suggest that posterior vermis damage may increase drug impact on the addiction circuitry by regulating activity in the DCN. However, they raise further questions that will also be discussed.

【 授权许可】

Unknown   
Copyright © 2023 Melchor-Eixea, Guarque-Chabrera, Sanchez-Hernandez, Ibáñez-Marín, Pastor and Miquel.