In vitro enzymatic degradation of the PTMC/cross-linked PEGDA blends

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Hong Cui¹  Chenchao Wang²  Wei Li³  Liqun Yang³  Miao Jiang³  Yu Sui³  Meina Lin³  Yongping Lu³  Xiang Ni³  Jing Guo³ 

[1] Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China;Department of Plastic Surgery, First Hospital of China Medical University, Shenyang, China;Liaoning Research Institute of Family Planning, The Affiliated Reproductive Hospital of China Medical University, Shenyang, China;

关键词: poly(trimethylene carbonate);    PEGDA;    UV cross-linking;    enzymatic degradation;    lipase;   

DOI  :  10.3389/fbioe.2023.1253221

 received in 2023-07-05, accepted in 2023-08-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: Poly(1,3-trimethylene carbonate) (PTMC) is a flexible amorphous polymer with good degradability and biocompatibility. The degradation of PTMC is critical for its application as a degradable polymer, more convenient and easy-to-control cross-linking strategies for preparing PTMC are required.Methods: The blends of poly(trimethylene carbonate) (PTMC) and cross-linked poly(ethylene glycol) diacrylate (PEGDA) were prepared by mixing photoactive PEGDA and PTMC and subsequently photopolymerizing the mixture with uv light. The physical properties and in vitro enzymatic degradation of the resultant PTMC/cross-linked PEGDA blends were investigated.Results: The results showed that the gel fraction of PTMC/cross-linked PEGDA blends increased while the swelling degree decreased with the content of PEGDA dosage. The results of in vitro enzymatic degradation confirmed that the degradation of PTMC/cross-linked PEGDA blends in the lipase solution occurred under the surface erosion mechanism, and the introduction of the uv cross-linked PEGDA significantly improved the resistance to lipase erosion of PTMC; the higher the cross-linking degree, the lower the mass loss.Discussion: The results indicated that the blends/cross-linking via PEGDA is a simple and effective strategy to tailor the degradation rate of PTMC.

【 授权许可】

Unknown   
Copyright © 2023 Li, Lin, Wang, Lu, Sui, Ni, Guo, Jiang, Yang and Cui.