Association of systemic immune inflammatory index with all-cause and cause-specific mortality in hypertensive individuals: Results from NHANES

Frontiers in Immunology

Immunology

Miaohan Qiu¹  Yaling Han¹  Yi Li¹  Jing Li¹  Sicong Ma¹  Yang Cao²  Pengxiao Li²  Yudong Yan²  Yan Zhang³ 

[1] The Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, Liaoning, China;The Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, Liaoning, China;The Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi’an, Shanxi, China;The Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi’an, Shanxi, China;

关键词: systemic immune-inflammation index;    hypertension;    population-based study;    NHANES;    cross-sectional study;   

DOI  :  10.3389/fimmu.2023.1087345

 received in 2022-11-02, accepted in 2023-01-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe relationship between the systemic immune inflammatory index (SII) and the prognosis of hypertensive patients is unclear. This study aims to explore the association of SII with all-cause and cause-specific mortality in patients with hypertension.MethodsThis study included 8524 adults with hypertension from the National Health and Nutritional Examination Surveys (NHANES) 2011–2018, and followed for survival through December 31, 2019. Cox proportional hazards models were used to investigate the associations between SII and mortality from all causes, cardiovascular disease (CVD), and cancer. Restricted cubic spline, piecewise linear regression, subgroup and sensitivity analyses were also used.ResultsDuring a median follow-up of 4.58 years, 872 all-cause deaths occurred. After adjusting for covariates, higher SII was significantly associated with an elevated risk of CVD mortality. There was a 102% increased risk of CVD mortality per one-unit increment in natural log-transformed SII (lnSII) (P < 0.001). Consistent results were also observed when SII was examined as categorical variable (quartiles). The associations of SII with all-cause and cancer mortality were detected as U-shaped with threshold values of 5.97 and 6.18 for lnSII respectively. Below thresholds, higher SII was significantly associated with lower all-cause mortality (HR=0.79, 95%CI=0.64-0.97) and cancer mortality (HR=0.73, 95%CI=0.53-1.00). Above thresholds, SII was significantly positive associated with all-cause mortality (HR=1.93, 95%CI=1.55-2.40) and cancer mortality (HR=1.93, 95%CI=1.22-3.05). The results were robust in subgroup and sensitivity analyses.ConclusionHigher SII (either as a continuous or categorical variable) were significantly associated with a higher risk of CVD mortality. The U-shaped associations were observed between SII and all-cause and cancer mortality.

【 授权许可】

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Copyright © 2023 Cao, Li, Zhang, Qiu, Li, Ma, Yan, Li and Han