Associations between smoking status and infertility: a cross-sectional analysis among USA women aged 18-45 years

Frontiers in Endocrinology

Endocrinology

Li Wan¹  Sijie He¹ 

[1] Department of Pharmacy, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: smoking status;    infertility;    NHANES;    cross-sectional analysis;    population-based study;   

DOI  :  10.3389/fendo.2023.1140739

 received in 2023-01-16, accepted in 2023-04-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundAlthough many studies have proven the harmful effects of smoking on human health, the associations between smoking status and infertility are limited in large epidemiologic studies. We aimed to investigate the associations between smoking status and infertility among child-bearing women in the United States of America (USA).MethodsA total of 3,665 female participants (aged 18-45) from the National Health and Nutrition Examination Survey (NHANES) (2013-2018) were included in this analysis. All data were survey-weighted, and corresponding logistic regression models were performed to investigate the associations between smoking status and infertility.ResultsIn a fully adjusted model, the risk of infertility was found to be increased by 41.8% among current smokers compared to never smokers (95% CI: 1.044-1.926, P=0.025). In the subgroup analysis, the odds ratios (95% CI) of the risk of infertility for current smokers were 2.352 (1.018-5.435) in the unadjusted model for Mexican American, 3.675 (1.531-8.820) in the unadjusted model but 2.162 (0.946-4.942) in fully adjusted model for people aged 25-31, 2.201 (1.097-4.418) in the unadjusted model but 0.837 (0.435-1.612) in fully adjusted model for people aged 32-38.ConclusionCurrent smokers was associated with a higher risk of infertility. The underlying mechanism of these correlations still needs more research. Our findings indicated that quitting smoking may serve as a simple index to reduce the risk of infertility.

【 授权许可】

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