Frontiers in Nutrition | |
The relationship between vitamin K and metabolic dysfunction-associated fatty liver disease among the United States population: National Health and Nutrition Examination Survey 2017–2018 | |
Nutrition | |
Jiale Huang1  Xinyue Wang2  Jian Gao3  Wei Zhang4  Hongwei Li4  | |
[1] Department of Clinical Nutrition, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;Department of Nutrition, Xiamen Clinical Research Center for Cancer Therapy, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian province, China;Department of Nutrition, Zhongshan Hospital, Fudan University, Shanghai, China;School of Public Health, Xiamen University, Xiamen, China; | |
关键词: vitamin K; metabolic dysfunction-associated fatty liver disease; dietary supplements; NHANES; cross-sectional analysis; | |
DOI : 10.3389/fnut.2023.1086477 | |
received in 2022-11-01, accepted in 2023-03-28, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
BackgroundThe effect of vitamin K is associated with several pathological processes in fatty liver. However, the association between vitamin K levels and metabolic dysfunction-associated fatty liver disease (MAFLD) remains unclear.ObjectiveHere, we investigated the relationship between vitamin K intake and MAFLD risk by employing the American National Health and Nutrition Examination Surveys (NHANES) including 3,571 participants.MethodsMAFLD was defined as hepatic steatosis with one or more of the following: overweight or obesity, type 2 diabetes, or >2 other metabolic risk abnormalities. The total vitamin K was the sum of dietary and supplement dietary intake. The relationship of between log10(vitamin K) and MAFLD was investigated using survey-weighted logistic regression and stratified analysis, with or without dietary supplementation.ResultsThe MAFLD population had a lower vitamin K intake than the non-MAFLD population (p = 0.024). Vitamin K levels were inversely associated with MAFLD in the fully adjusted model (OR = 0.488, 95% CI: 0.302–0.787, p = 0.006). Consistent results were seen in the group without dietary supplements (OR = 0.373, 95% CI: 0.186–0.751, p = 0.009) but not in the group consuming dietary supplements (OR = 0.489, 95% CI: 0.238–1.001, p = 0.050).ConclusionVitamin K intake may be a protective factor for MAFLD, especially for individual not using dietary supplements. Nevertheless, more high-quality prospective studies are needed to clarify the causal relationship between them.
【 授权许可】
Unknown
Copyright © 2023 Wang, Zhang, Huang, Li and Gao.
【 预 览 】
Files | Size | Format | View |
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RO202310106674443ZK.pdf | 650KB | download |