Variations on the theme: focus on cerebellum and emotional processing

Frontiers in Systems Neuroscience

Neuroscience

Lisa Mapelli¹  Claudia Casellato¹  Yuhe Li¹  Dianela A. Osorio Becerra¹  Camilla Ciapponi¹  Egidio D’Angelo²  Dimitri Rodarie³ 

[1] Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy;Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy;Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy;Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy;Centro Ricerche Enrico Fermi, Rome, Italy;

关键词: cerebellum;    emotion;    Purkinje cell;    microcircuit functioning;    modular organization;   

DOI  :  10.3389/fnsys.2023.1185752

 received in 2023-03-13, accepted in 2023-04-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

The cerebellum operates exploiting a complex modular organization and a unified computational algorithm adapted to different behavioral contexts. Recent observations suggest that the cerebellum is involved not just in motor but also in emotional and cognitive processing. It is therefore critical to identify the specific regional connectivity and microcircuit properties of the emotional cerebellum. Recent studies are highlighting the differential regional localization of genes, molecules, and synaptic mechanisms and microcircuit wiring. However, the impact of these regional differences is not fully understood and will require experimental investigation and computational modeling. This review focuses on the cellular and circuit underpinnings of the cerebellar role in emotion. And since emotion involves an integration of cognitive, somatomotor, and autonomic activity, we elaborate on the tradeoff between segregation and distribution of these three main functions in the cerebellum.

【 授权许可】

Unknown   
Copyright © 2023 Ciapponi, Li, Osorio Becerra, Rodarie, Casellato, Mapelli and D’Angelo.