Journal of Biological Researches | 卷:11 |
Abnormal struktur histologis korteks cerebellar tikus dengan normal foliasi akibat iradiasi sinar X masa postnatal | |
WIN DARMANTO1  | |
[1] Jurusan Biologi, FMIPA Universitas Airlangga, Surabaya; | |
关键词: cerebellum; foliation; postnatal day; Purkinje cell; X-irradiation; | |
DOI : 10.23869/bphjbr.11.1.20053 | |
来源: DOAJ |
【 摘 要 】
Our previous experiment showed that prenatal exposure of rats to X-irradiation on gestation day 21st as the late gestation periodcauses heterotopic Purkinje cells and abnormal foliation of the cerebellum. However the present study observed the heterotopik ofPurkinje cell layer following exposure of the rats to X-irradiation on postnatal day (P) 4, without abnormal foliation of the cerebellum.It also demonstrated the process of re-derangement of Purkinje cells. Rat pups were exposed to 2.5 Gy X-irradiation and the cerebellumwas examined histologically and by immunohistochemistry to identify Purkinje cells. At 6 h after exposure, extensive cell death wasobserved in the external granular layer (EGL) of the cerebellum. By P7 (3 days after exposure), while Purkinje cells with well developeddendrites aligned underneath the EGL in the control cerebellum, Purkinje cells with shorter and abnormally oriented dendrites failedto align and re-deranged in the heterotopic location. On adult, the cerebellum of rats irradiated was observed almost normal folialdeveloped. It is strong support previous study that the critical stage for cerebellar abnormal foliation caused X-irradiation is in theearly postnatal period.
【 授权许可】
Unknown