Role of Probiotics in Halitosis of Oral Origin: A Systematic Review and Meta-Analysis of Randomized Clinical Studies

Frontiers in Nutrition

Nutrition

Cinthia Rodríguez¹  Ana Suárez²  Nansi López-Valverde³  Antonio López-Valverde³  Juan Manuel Aragoneses⁴  Bruno Macedo de Sousa⁵ 

[1] Department of Dentistry, Universidad Federico Henríquez y Carvajal, Santo Domingo, Dominican Republic;Department of Preclinical Dentistry, School of Biomedical Sciences, Universidad Europea de Madrid, Madrid, Spain;Department of Surgery, University of Salamanca, Salamanca, Spain;Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain;Faculty of Dentistry, Universidad Alfonso X El Sabio, Madrid, Spain;Institute for Occlusion and Orofacial Pain Faculty of Medicine, University of Coimbra, Coimbra, Portugal;

关键词: probiotics;    halitosis;    oral malodor;    bad breath;    oral health;    randomized clinical trial;   

DOI  :  10.3389/fnut.2021.787908

 received in 2021-11-12, accepted in 2021-12-30,  发布年份 2022

来源: Frontiers

【 摘 要 】

Halitosis or oral malodor is a condition caused by the putrefaction of sulfur-containing amino acids. It affects 30–50% of the population and causes social rejection, reducing quality of life, and self-esteem. Probiotics, especially Lactobacillus species, have been proposed for the treatment of genuine halitosis, due to their ability to reduce bacterial colonization. Our objective was to evaluate their use for the treatment of oral halitosis. Applying the PRISMA statement guidelines, we searched PubMed, EMBASE, and Web of Science databases for scientific articles from the last 15 years, up to July 2021. The keywords used were “Probiotics”; “Halitosis”; “Mouth diseases”; “Oral health”; “Humans”; “Randomized Clinical Trials” according to the question, “Are probiotics effective for the reduction or elimination of oral halitosis?” Fourteen studies were identified, although only four met the inclusion criteria. We evaluated 283 participants treated with two different probiotics, with a follow-up of at least 2 weeks. Risk of bias was assessed using the Cochrane Collaboration tool. A fixed-effects meta-analysis was performed. No statistical significance was found (p = 0.53). Despite the limitations of this meta-analysis, we believe that some probiotics have a beneficial effect on halitosis, although more clinical trials are needed to establish real evidence on this aspect.Systematic Review Registration: https://doi.org/10.37766/inplasy2021.9.0009, identifier: INPLASY20211900.

【 授权许可】

Unknown   
Copyright © 2022 López-Valverde, López-Valverde, Macedo de Sousa, Rodríguez, Suárez and Aragoneses.