Dental health of patients with X-linked hypophosphatemia: A controlled study

Frontiers in Oral Health

Oral Health

Karin Garming-Legert¹  Tobias Regnstrand¹  Amila Larsson²  Pia Skott²  Sigridur Björnsdottir³  Outi Mäkitie⁴ 

[1] Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden;Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden;Public Dental Health Service Stockholm AB, Stockholm, Sweden;Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden;Department of Pediatric Research, Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Department of Clinical Genetics, Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden;Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;

关键词: dental;    endodontic;    infections;    periodontal;    XLH;   

DOI  :  10.3389/froh.2023.1087761

 received in 2022-11-02, accepted in 2023-02-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThe present study compared the dental health of patients with X-linked hypophosphatemia (XLH) with healthy age- and gender-matched controls to increase our knowledge of the impact of XLH on oral health.Materials and methodsTwenty-two adult patients with XLH in the Stockholm region of Sweden were referred to the Department of Orofacial Medicine at Karolinska Institutet for an extended clinical and radiological examination. Pre-existing radiologic examinations of 44 healthy age- and gender-matched controls were retrieved from the Department of Oral Radiology, at Karolinska Institutet.ResultsThe 22 patients with XLH (15 females, median age 38 years, range 20–71; 7 males, median age 49 years, range 24–67) had a significantly higher number of root-filled teeth compared to healthy controls (p = .001). In the XLH group, females had significantly better oral health than males, especially concerning endodontic and cariological status (p's = .01 and .02, respectively). Periodontal status differed non-significantly between the XLH and control groups.ConclusionPatients with XLH had a significantly lower oral health status compared to a healthy population especially concerning endodontic conditions. Male patients with XLH had a higher risk of poor oral health compared to female patients with XLH.

【 授权许可】

Unknown   
© 2023 Larsson, Regnstrand, Skott, Mäkitie, Björnsdottir and Garming-Legert.