Socioeconomic status may affect association of vegetable intake with risk of ischemic cardio-cerebral vascular disease: a Mendelian randomization study

Frontiers in Nutrition

Nutrition

Jiutian Huang¹  Jianing Du¹  Ziyi He¹  Minhui Xu¹  Yun-tao Zhao² 

[1] Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, China;Department of Cardiology, Aerospace Center Hospital, Beijing, China;

关键词: vegetable intake;    socioeconomic status;    ischemic cardiovascular disease;    ischemic cerebrovascular disease;    Mendelian randomization;   

DOI  :  10.3389/fnut.2023.1161175

 received in 2023-02-21, accepted in 2023-06-23,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPrevious studies found that increasing vegetable intake benefits are reduced after adjustment for socioeconomic factors. Using genetic variation as an instrumental variable for vegetable intake and socioeconomic status, we investigated the relationship between vegetable intake and ischemic cardio-cerebral vascular diseases and focused on whether socioeconomic status was a possible confounder.MethodsFrom three independent genome-wide association studies, we extracted instrumental variables reflecting raw and cooked vegetable intake, which were used to perform Mendelian randomization analysis. To evaluate the effects of socioeconomic factors on vegetable intake, univariate and multivariate Mendelian randomization analyses were performed using single nucleotide polymorphisms representing education attainment and household income reported in the literature. We also performed outlier assessment and a series of sensitivity analyses to confirm the results.ResultsGenetically predicted raw and cooked vegetable intake were not associated with any ischemic cardio-cerebral vascular diseases and lipid components after Bonferroni correction. Univariate Mendelian randomized analysis revealed that raw vegetable intake was positively correlated with education attainment (β = 0.04, p = 0.029) and household income (β = 0.07, p < 0.001). Multivariate Mendelian randomized model showed a positive correlation between household income and raw vegetable intake (β = 0.06, p = 0.004). Socioeconomic status was closely associated with eating habits and lifestyle related to the risk of cardiovascular diseases.ConclusionGenetically determined raw and cooked vegetable intake was not associated with significant benefits in terms of ischemic cardio-cerebral vascular diseases while genetically determined socioeconomic status may have an impact on vegetable intake. Socioeconomic status, which was closely associated with other eating habits and lifestyle, may affect the association between vegetable intake and ischemic cardio-cerebral vascular diseases.

【 授权许可】

Unknown   
Copyright © 2023 Huang, He, Xu, Du and Zhao.