Association of Vegetable and Animal Flesh Intake with Inflammation in Pregnant Women from India

Nutrients

Vandana Kulkarni¹  Mallika Alexander¹  Prasad Deshpande¹  Amita Gupta¹  LauraE. Caulfield²  Cheng-Shiun Leu³  Rupak Shivakoti⁴  Su Yadana⁴  JyotiS. Mathad⁵  Ramesh Bhosale⁶  Shilpa Naik⁶  SameeraA. Talegawkar⁷  Kripa Rajagopalan⁸  Mariana Araujo-Pereira⁹  BrunoB. Andrade⁹  Pavan Kumar^1,10  Subash Babu^1,10 

[1] Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Pune 380016, India;Center for Human Nutrition, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA;Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY 10032, USA;Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA;Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA;Department of Obstetrics and Gynecology, Byramjee Jeejeebhoy Government Medical College, Pune 380016, India;Departments of Exercise and Nutrition Sciences and Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA;Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA;Instituto Goncalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil;International Center for Excellence in Research, National Institutes of Health, National Institute for Research in Tuberculosis, Chennai 600031, India;

关键词: vegetable intake;    meat intake;    monocyte activation;    gut barrier;    inflammation;    pregnancy;   

DOI  :  10.3390/nu12123767

来源: DOAJ

【 摘 要 】

In pregnant women, studies are lacking on the relationship of vegetable and animal flesh (poultry, red meat and seafood) intake with inflammation, especially in low- and middle-income countries. We conducted a cohort study of pregnant women receiving antenatal care at BJ Medical College in Pune, India. The dietary intake of pregnant women was queried in the third trimester using a validated food frequency questionnaire. Twelve inflammatory markers were measured in plasma samples using immunoassays. Only 12% of the study population were vegetarians, although animal flesh intake levels were lower compared to Western populations. In multivariable models, higher intakes of total vegetables were associated with lower levels of the T-helper (Th) 17 cytokine interleukin (IL)-17a (p = 0.03) and the monocyte/macrophage activation marker soluble CD163 (sCD163) (p = 0.02). Additionally, higher intakes of poultry were negatively associated with intestinal fatty-acid binding protein (I-FABP) levels (p = 0.01), a marker of intestinal barrier dysfunction and Th2 cytokine IL-13 (p = 0.03), and higher seafood was associated with lower IL-13 (p = 0.005). Our data from pregnant women in India suggest that a higher quality diet emphasizing vegetables and with some animal flesh is associated with lower inflammation. Future studies should confirm these findings and test if modulating vegetables and animal flesh intake could impact specific aspects of immunity and perinatal health.

【 授权许可】

Unknown