Metabolic biomarkers of risperidone-induced weight gain in drug-naïve patients with schizophrenia

Frontiers in Psychiatry

Psychiatry

Mei Juan Li¹  Yongping Zhao¹  Jie Li¹  Yuying Qiu¹  Yeqing Dong¹  Wei Sun¹  Changyong Jiang¹  Gang Li² 

[1] Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China;Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China;Chifeng Anding Hospital, Inner Mongolia Autonomous Region, Chifeng, China;

关键词: schizophrenia;    weight gain;    risperidone;    targeted metabolomics;    biomarkers;   

DOI  :  10.3389/fpsyt.2023.1144873

 received in 2023-01-15, accepted in 2023-03-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundRisperidone is a commonly prescribed antipsychotic drug with a potential side effect of weight gain. However, the pathophysiological mechanism is still poorly understood. Here, we sought to identify potential biomarkers of risperidone-induced weight gain by using a targeted metabolomics approach.MethodsWe enrolled 30 subjects who received risperidone monotherapy for 8  weeks from a prospective longitudinal cohort study for drug-naïve schizophrenia patients. Plasma metabolites were measured by targeted metabolomics Biocrates MxP® Quant 500 Kit at baseline and 8-week follow-up.ResultsAfter 8  weeks of risperidone treatment, the levels of 48 differential metabolites were upregulated, including lysophosphatidylcholines (2), phosphatidylcholines (PC) (8), cholesteryl esters (CE) (3), and triglycerides (35), while 6 differential metabolites namely PC aa C38:6, methionine (Met), α-aminobutyric acid (AABA), TrpBetaine, CE (22:6), and Taurocholic acid (TCA) were downregulated. Interestingly, the reduction of PC aa C38:6, AABA and CE (22:6) was linearly related with increased BMI. Further multiple regression analysis showed that the changes of PC aa C38:6 and AABA were independent contributors of increased BMI. In addition, baseline levels of PC aa C36:5, CE (20:5) and AABA had positive relationships with the change of BMI.ConclusionOur findings indicate phosphatidylcholines and amino acids may serve as biomarkers for risperidone-induced weight gain.

【 授权许可】

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Copyright © 2023 Qiu, Dong, Sun, Li, Li, Zhao, Jiang and Li.