The maintenance of modified electroconvulsive therapy combined with risperidone is better than risperidone alone in preventing relapse of schizophrenia and improving cognitive function

Arquivos de Neuro-Psiquiatria

关键词: schizophrenia;    electroconvulsive therapy;    risperidone;    cognition;   

DOI  :  10.1590/0004-282X20160130

来源: DOAJ

【 摘 要 】

ABSTRACTObjectiveTo evaluate the effect of maintenance modified electroconvulsive therapy (MECT) on schizophrenic patients.MethodsFrom June 2012 to June 2014, 62 patients with schizophrenia, who had recovered from a successful course of acute MECT, were recruited. Thirty-one patients received maintenance MECT and risperidone, as the experimental group. Another 31 patients were enrolled in the control group, and received risperidone only. The effects on cognitive functions, clinical symptoms and relapse rate were determined.ResultsPatients in the experimental group had a lower relapse rate and longer relapse-free survival time than the controls. Relative to the baseline evaluation, patients showed statistically significant improvement in verbal memory and visual memory. At the final assessment, the scores of verbal and visual memory were remarkably lower in the experimental group than the controls but there was no significant difference in other tests.ConclusionMaintenance MECT plus medication is superior to medication alone in preventing relapse and improving cognitive function.

【 授权许可】

Unknown