The potential of fungi in the bioremediation of pharmaceutically active compounds: a comprehensive review

Frontiers in Microbiology

Microbiology

Sesan Aransiola¹  Christiana E. Aruwa²  Toyin D. Alabi³  John Omame⁴  Ayodeji Amobonye⁵  Japareng Lalung⁶ 

[1] Bioresources Development Centre, National Biotechnology Development Agency, P.M.B. Onipanu, Ogbomosho, Nigeria;Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban, South Africa;Department of Life Sciences, Baze University, Abuja, Nigeria;National Environmental Standards and Regulations Enforcement Agency, Lagos Field Office, Lagos, Nigeria;School of Industrial Technology, Universiti Sains Malaysia, Penang, Malaysia;School of Industrial Technology, Universiti Sains Malaysia, Penang, Malaysia;Centre for Global Sustainability Studies, Universiti Sains Malaysia, Penang, Malaysia;

关键词: bioremediation;    degradation;    environment;    fungi;    drug compounds;    pharmaceutically active compounds;    pollution;    wastewater;   

DOI  :  10.3389/fmicb.2023.1207792

 received in 2023-04-18, accepted in 2023-06-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

The ability of fungal species to produce a wide range of enzymes and metabolites, which act synergistically, makes them valuable tools in bioremediation, especially in the removal of pharmaceutically active compounds (PhACs) from contaminated environments. PhACs are compounds that have been specifically designed to treat or alter animal physiological conditions and they include antibiotics, analgesics, hormones, and steroids. Their detrimental effects on all life forms have become a source of public outcry due their persistent nature and their uncontrolled discharge into various wastewater effluents, hospital effluents, and surface waters. Studies have however shown that fungi have the necessary metabolic machinery to degrade PhACs in complex environments, such as soil and water, in addition they can be utilized in bioreactor systems to remove PhACs. In this regard, this review highlights fungal species with immense potential in the biodegradation of PhACs, their enzymatic arsenal as well as the probable mechanism of biodegradation. The challenges encumbering the real-time application of this promising bioremediative approach are also highlighted, as well as the areas of improvement and future perspective. In all, this paper points researchers to the fact that fungal bioremediation is a promising strategy for addressing the growing issue of pharmaceutical contamination in the environment and can help to mitigate the negative impacts on ecosystems and human health.

【 授权许可】

Unknown   
Copyright © 2023 Amobonye, Aruwa, Aransiola, Omame, Alabi and Lalung.