A novel zinc metabolism-related gene signature to predict prognosis and immunotherapy response in lung adenocarcinoma

Frontiers in Immunology

Immunology

Wuguang Chang¹  Hongmu Li¹  Si-Yu Wang¹  Wei Ou¹ 

[1] State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China;

关键词: zinc;    zinc metabolism;    biomarker;    prognosis;    lung adenocarcinoma;    immunotherapy;   

DOI  :  10.3389/fimmu.2023.1147528

 received in 2023-01-18, accepted in 2023-03-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundZinc is a key mineral element in regulating cell growth, development, and immune system. We constructed the zinc metabolism-related gene signature to predict prognosis and immunotherapy response for lung adenocarcinoma (LUAD).MethodsZinc metabolism-associated gene sets were obtained from Molecular Signature Database. Then, the zinc metabolism-related gene signature (ZMRGS) was constructed and validated. After combining with clinical characteristics, the nomogram for practical application was constructed. The differences in biological pathways, immune molecules, and tumor microenvironment (TME) between the different groups were analyzed. Tumor Immune Dysfunction and Exclusion algorithm (TIDE) and two immunotherapy datasets were used to evaluate the immunotherapy response.ResultsThe signature was constructed according to six key zinc metabolism-related genes, which can well predict the prognosis of LUAD patients. The nomogram also showed excellent prediction performance. Functional analysis showed that the low-risk group was in the status of immune activation. More importantly, the lower risk score of LUAD patients showed a higher response rate to immunotherapy.ConclusionThe state of zinc metabolism is closely connected to prognosis, tumor microenvironment, and response to immunotherapy. The zinc metabolism-related signature can well evaluate the prognosis and immunotherapy response for LUAD patients.

【 授权许可】

Unknown   
Copyright © 2023 Chang, Li, Ou and Wang