Potential therapeutic mechanism of deep brain stimulation of the nucleus accumbens in obsessive-compulsive disorder

Frontiers in Cellular Neuroscience

Neuroscience

Mengqi Wang¹  Linglong Xiao¹  Yifeng Shi¹  Yangyang Xu¹  Wei Pan¹  Wei Wang¹  Bo Su²  Jie Zhang³  Lin Bai³  Wen Zheng⁴  Luolan Gui⁴  Bin Li⁵ 

[1] Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China;Histology and Imaging Platform, Core Facilities of West China Hospital, Sichuan University, Chengdu, Sichuan, China;Histology and Imaging Platform, Core Facilities of West China Hospital, Sichuan University, Chengdu, Sichuan, China;Key Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China;Laboratory of Clinical Proteomics and Metabolomics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Institutes for Systems Genetics, Sichuan University, Chengdu, Sichuan, China;Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China;

关键词: deep brain stimulation;    therapy;    nucleus accumbens;    obsessive-compulsive disorder;    in vivo;    neurotransmitters;   

DOI  :  10.3389/fncel.2022.1057887

 received in 2022-09-30, accepted in 2022-12-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

Deep brain stimulation (DBS) of the nucleus accumbens (NAc) (NAc-DBS) is an effective solution to refractory obsessive-compulsive disorder (OCD). However, evidence for the neurobiological mechanisms of OCD and the effect of NAc-DBS is still lacking. One hypothesis is that the electrophysiological activities in the NAc are modulated by DBS, and another hypothesis is that the activities of neurotransmitters in the NAc are influenced by DBS. To investigate these potential alterations, rats with quinpirole (QNP)- induced OCD were treated with DBS of the core part of NAc. Then, extracellular spikes (SPK) and local field potentials (LFP) in the NAc were recorded, and the levels of relevant neurotransmitters and related proteins were measured. Analysis of SPK revealed that the firing rate was decreased and the firing pattern was changed after NAc-DBS, and analysis of LFP showed that overall power spectral density (PSD) levels were reduced after NAc-DBS. Additionally, we found that the relative powers of the theta band, alpha band and beta band were increased in OCD status, while the relative powers of the delta band and gamma band were decreased. This pathological pattern of power distribution was reformed by NAc-DBS. Furthermore, we found that the local levels of monoamines [dopamine (DA) and serotonin (5-HT)] and amino acids [glutamate (Glu) and gamma-aminobutyric acid (GABA)] in the NAc were increased in OCD status, and that the expression of the two types of DA receptors in the NAc exhibited an opposite change. These abnormalities could be reversed by NAc-DBS. These findings provide a more comprehensive understanding about the function of the NAc in the pathophysiology of OCD and provide more detailed evidence for the potential effect of NAc-DBS.

【 授权许可】

Unknown   
Copyright © 2023 Shi, Wang, Xiao, Gui, Zheng, Bai, Su, Li, Xu, Pan, Zhang and Wang.