Cytoplasmic DNAs: Sources, sensing, and roles in the development of lung inflammatory diseases and cancer

Frontiers in Immunology

Immunology

Faiza Naz¹  Jianzhang Lu²  Xintong He²  Ye Sun²  Jian Liu³  Shenglin Ma⁴ 

[1] Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China;Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, China;Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China;Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, China;College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom;Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China;Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, China;College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom;Cancer Center, Zhejiang University, Hangzhou, China;Biomedical and Heath Translational Research Center of Zhejiang Province, Haining, China;Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, China;Hangzhou Cancer Institution, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China;Cancer Center, Zhejiang University, Hangzhou, China;

关键词: cytoplasmic DNA;    innate immunity;    interferon;    immunotherapy;    COVID-19;    cytokine;    STING;    lung cancer;   

DOI  :  10.3389/fimmu.2023.1117760

 received in 2022-12-06, accepted in 2023-03-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cytoplasmic DNA is emerging as a pivotal contributor to the pathogenesis of inflammatory diseases and cancer, such as COVID-19 and lung carcinoma. However, the complexity of various cytoplasmic DNA-related pathways and their crosstalk remains challenging to distinguish their specific roles in many distinct inflammatory diseases, especially for the underlying mechanisms. Here, we reviewed the latest findings on cytoplasmic DNA and its signaling pathways in inflammatory lung conditions and lung cancer progression. We found that sustained activation of cytoplasmic DNA sensing pathways contributes to the development of common lung diseases, which may result from external factors or mutations of key genes in the organism. We further discussed the interplays between cytoplasmic DNA and anti-inflammatory or anti-tumor effects for potential immunotherapy. In sum, this review aids in understanding the roles of cytoplasmic DNAs and exploring more therapeutic strategies.

【 授权许可】

Unknown   
Copyright © 2023 He, Sun, Lu, Naz, Ma and Liu