Molecular characterization and immune responsive expression of feline MDA5 gene

The Journal of Veterinary Medical Science

Ryota KOBA¹ 

[1] Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252-0880, Japan

关键词: cat;    innate immunity;    interferon;    Melanoma differentiation-associated gene 5 (MDA5);   

DOI  :  10.1292/jvms.17-0278

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The retinoic acid-inducible gene-I-like receptor (RLR) family is a group of cytosolic RNA helicase proteins that play an important role in sensing viral RNAs. Melanoma differentiation-associated gene 5 (MDA5), an RLR protein, recognizes viral double-stranded RNA and 5’-triphosphate single-stranded RNA in the cytoplasm for the expression of type I interferon (IFN). The expression of MDA5 is also induced by type I IFN. In the present study, we determined the complete coding sequence of the feline MDA5 gene, and analyzed its structure. In addition, we examined tissue expression patterns, inducibilities of the feline MDA5 by polyinosinic-polycytidylic acid and type I IFN, and a functional role of feline MDA5 on type I IFN expression.

【 授权许可】

Unknown