Role of flavonoids in controlling obesity: molecular targets and mechanisms

Frontiers in Nutrition

Nutrition

Nabil Miled¹  Mohmmad Younus Wani¹  Arif Mohamed¹  Samson Mathews Samuel²  Dietrich Büsselberg²  Ali Chaari³  Anns Mahboob³  Sofiane Ghorbel⁴ 

[1] College of Science, University of Jeddah, Jeddah, Saudi Arabia;Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, Qatar;Department of Pre-medical Education, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, Qatar;Science and Arts at Khulis, University of Jeddah, Jeddah, Saudi Arabia;

关键词: anti-obesity therapy;    flavonoids;    metabolic syndrome;    natural compounds;    obesity;   

DOI  :  10.3389/fnut.2023.1177897

 received in 2023-03-02, accepted in 2023-04-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

Obesity presents a major health challenge that increases the risk of several non-communicable illnesses, such as but not limited to diabetes, hypertension, cardiovascular diseases, musculoskeletal and neurological disorders, sleep disorders, and cancers. Accounting for nearly 8% of global deaths (4.7 million) in 2017, obesity leads to diminishing quality of life and a higher premature mortality rate among affected individuals. Although essentially dubbed as a modifiable and preventable health concern, prevention, and treatment strategies against obesity, such as calorie intake restriction and increasing calorie burning, have gained little long-term success. In this manuscript, we detail the pathophysiology of obesity as a multifactorial, oxidative stress-dependent inflammatory disease. Current anti-obesity treatment strategies, and the effect of flavonoid-based therapeutic interventions on digestion and absorption, macronutrient metabolism, inflammation and oxidative stress and gut microbiota has been evaluated. The use of several naturally occurring flavonoids to prevent and treat obesity with a long-term efficacy, is also described.

【 授权许可】

Unknown   
Copyright © 2023 Mahboob, Samuel, Mohamed, Wani, Ghorbel, Miled, Büsselberg and Chaari.