Impact of puberty, sex determinants and chronic inflammation on cardiovascular risk in young people

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Coziana Ciurtin¹  Junjie Peng¹  George A. Robinson¹  Elizabeth C. Jury²  Gary Butler³  Crystal Marruganti⁴  Francesco D’Aiuto⁴  Amal Allalou⁵ 

[1]Centre for Adolescent Rheumatology Versus Arthritis, University College London, London, United Kingdom

[2]Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom

[3]Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom

[4]Department of Paediatric Endocrinology, University College London Hospital, London, United Kingdom

[5]Institute of Child Health, University College London, London, United Kingdom

[6]Eastman Dental Hospital, University College London Hospital, London, United Kingdom

[7]University College London Medical School, University College London, London, United Kingdom

关键词: cardiovascular risk factors;    children and young poeple;    chronic inflammation;    puberty;    obesity;    sex determinants;   

DOI  :  10.3389/fcvm.2023.1191119

 received in 2023-03-21, accepted in 2023-06-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Worrying trends of increased cardiovascular disease (CVD) risk in children, adolescents and young people in the Modern Era have channelled research and public health strategies to tackle this growing epidemic. However, there are still controversies related to the dynamic of the impact of sex, age and puberty on this risk and on cardiovascular health outcomes later in life. In this comprehensive review of current literature, we examine the relationship between puberty, sex determinants and various traditional CVD-risk factors, as well as subclinical atherosclerosis in young people in general population. In addition, we evaluate the role of chronic inflammation, sex hormone therapy and health-risk behaviours on augmenting traditional CVD-risk factors and health outcomes, ultimately aiming to determine whether tailored management strategies for this age group are justified.

【 授权许可】

Unknown   
© 2023 Allalou, Peng, Robinson, Marruganti, D'Aiuto, Butler, Jury and Ciurtin.