Pharmacological impact of microRNAs in head and neck squamous cell carcinoma: Prevailing insights on molecular pathways, diagnosis, and nanomedicine treatment

Frontiers in Pharmacology

Pharmacology

Shalam M. Hussain¹  Ram Kumar Sahu²  Ayesha Farhana Syeda³  Damanbhalang Rynjah⁴  Padmanath Pegu⁴  Shekhar Chandra Bora⁴  Bedanta Bhattacharjee⁴  Jiyauddin Khan⁵ 

[1] Department of Clinical Pharmacy, College of Nursing and Health Sciences, Al-Rayyan Medical College, Madinah, Saudi Arabia;Department of Pharmaceutical Sciences, Hemvati Nandan Bahuguna Garhwal University (A Central University), Chauras Campus, Tehri Garhwal, Uttarakhand, India;Department of Pharmaceutics, Unaiza College of Pharmacy, Qassim University, Unaizah, Saudi Arabia;Girijananda Chowdhury Institute of Pharmaceutical Science, Tezpur, India;School of Pharmacy, Management and Science University, Shah Alam, Malaysia;

关键词: head and neck squamous cell carcinoma;    microRNA;    molecular signaling;    nanomedicine;    nanovaccines;   

DOI  :  10.3389/fphar.2023.1174330

 received in 2023-02-26, accepted in 2023-04-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Head and neck squamous cell carcinoma is a disease that most commonly produce tumours from the lining of the epithelial cells of the lips, larynx, nasopharynx, mouth, or oro-pharynx. It is one of the most deadly forms of cancer. About one to two percent of all neo-plasm-related deaths are attributed to head and neck squamous cell carcinoma, which is responsible for about six percent of all cancers. MicroRNAs play a critical role in cell proliferation, differentiation, tumorigenesis, stress response, triggering apoptosis, and other physiological process. MicroRNAs regulate gene expression and provide new diagnostic, prognostic, and therapeutic options for head and neck squamous cell carcinoma. In this work, the role of molecular signaling pathways related to head and neck squamous cell carcinoma is emphasized. We also provide an overview of MicroRNA downregulation and overexpression and its role as a diagnostic and prognostic marker in head and neck squamous cell carcinoma. In recent years, MicroRNA nano-based therapies for head and neck squamous cell carcinoma have been explored. In addition, nanotechnology-based alternatives have been discussed as a promising strategy in exploring therapeutic paradigms aimed at improving the efficacy of conventional cytotoxic chemotherapeutic agents against head and neck squamous cell carcinoma and attenuating their cytotoxicity. This article also provides information on ongoing and recently completed clinical trials for therapies based on nanotechnology.

【 授权许可】

Unknown   
Copyright © 2023 Bhattacharjee, Syeda, Rynjah, Hussain, Chandra Bora, Pegu, Sahu and Khan.