MicroRNAs in Head and Neck Squamous Cell Carcinoma (HNSCC) and Oral Squamous Cell Carcinoma (OSCC)

Cancers

Masashi Shiiba¹  Katsuhiro Uzawa² 

[1] Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University/1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan;

关键词: microRNA;    head and neck squamous cell carcinoma;    oral squamous cell carcinoma;   

DOI  :  10.3390/cancers2020653

来源: mdpi

【 摘 要 】

MicroRNAs (miRNAs) are small, noncoding RNAs which regulate cell differentiation, proliferation, development, cell cycle, and apoptosis. Expression profiling of miRNAs has been performed and the data show that some miRNAs are upregulated or downregulated in cancer. Several studies suggest that the expression profiles of miRNAs are associated with clinical outcomes. However, the set of miRNAs with altered expressing differs depending on the type of cancer, suggesting that it is important to understand which miRNAs are related to which cancers. Therefore, this review aimed to discuss potentially crucial miRNAs in head and neck squamous cell carcinoma (HNSCC) and oral squamous cell carcinoma (OSCC).

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.