Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials

Frontiers in Aging Neuroscience

Neuroscience

Haixia Ma¹  Yang Yang¹  Yuanpin Liao¹  Cui Lin²  Juanxia Zheng²  Muli Yu²  Jiao Lan²  Jifei Miao³ 

[1]Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China

[2]Shenzhen Bao’an Traditional Chinese Medicine Hospital, Shenzhen, China

[3]Shenzhen Bao’an Traditional Chinese Medicine Hospital, Shenzhen, China

[4]School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China

关键词: Alzheimer’s disease;    microglia;    amyloid-beta;    phagocytosis;    neuroinflammation;   

DOI  :  10.3389/fnagi.2023.1201982

 received in 2023-04-07, accepted in 2023-05-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by protein aggregation in the brain. Recent studies have revealed the critical role of microglia in AD pathogenesis. This review provides a comprehensive summary of the current understanding of microglial involvement in AD, focusing on genetic determinants, phenotypic state, phagocytic capacity, neuroinflammatory response, and impact on synaptic plasticity and neuronal regulation. Furthermore, recent developments in drug discovery targeting microglia in AD are reviewed, highlighting potential avenues for therapeutic intervention. This review emphasizes the essential role of microglia in AD and provides insights into potential treatments.

【 授权许可】

Unknown   
Copyright © 2023 Miao, Ma, Yang, Liao, Lin, Zheng, Yu and Lan.