Self-assembling peptides as immunomodulatory biomaterials

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Jeffrey D. Hartgerink¹  Andrea Hernandez²  Simon Young² 

[1] Department of Chemistry and Department of Bioengineering, Rice University, Houston, TX, United States;Katz Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, United States;

关键词: biomaterials;    self-assembling peptides (SAP);    cancer;    immunotherapy;    localized delivery;   

DOI  :  10.3389/fbioe.2023.1139782

 received in 2023-01-07, accepted in 2023-02-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Self-assembling peptides are a type of biomaterial rapidly emerging in the fields of biomedicine and material sciences due to their promise in biocompatibility and effectiveness at controlled release. These self-assembling peptides can form diverse nanostructures in response to molecular interactions, making them versatile materials. Once assembled, the peptides can mimic biological functions and provide a combinatorial delivery of therapeutics such as cytokines and drugs. These self-assembling peptides are showing success in biomedical settings yet face unique challenges that must be addressed to be widely applied in the clinic. Herein, we describe self-assembling peptides’ characteristics and current applications in immunomodulatory therapeutics.

【 授权许可】

Unknown   
Copyright © 2023 Hernandez, Hartgerink and Young.