Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial

Frontiers in Psychiatry

Psychiatry

Mojgan Golzy¹  Eric L. Garland²  Spencer Upton³  Alexander A. Brown⁴  Brett Froeliger⁴ 

[1] Biostatistics Unit, Department of Family and Community Medicine, School of Medicine, University of Missouri, Columbia, MO, United States;Center on Mindfulness and Integrative Health Intervention Development, College of Social Work, University of Utah, Salt Lake City, UT, United States;Department of Psychological Sciences, University of Missouri, Columbia, MO, United States;Department of Psychological Sciences, University of Missouri, Columbia, MO, United States;Department of Psychiatry, School of Medicine, University of Missouri, Columbia, MO, United States;Cognitive Neuroscience Systems Core Facility, University of Missouri, Columbia, MO, United States;

关键词: addiction;    smoking;    tobacco;    craving;    repetitive transcranial magnetic stimulation;    resting state fMRI;    right inferior frontal gyrus (rIFG);   

DOI  :  10.3389/fpsyt.2023.1166912

 received in 2023-02-15, accepted in 2023-05-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionFunctional and anatomical irregularities in the right inferior frontal gyrus (rIFG), a ventrolateral prefrontal region that mediates top-down inhibitory control over prepotent behavioral responding, are implicated in the ongoing maintenance of nicotine dependence (ND). However, there is little research on the effects of neuromodulation of the rIFG on smoking behavior, inhibitory control, and resting-state functional connectivity (rsFC) among individuals with ND.MethodsIn this double-blind, crossover, theta-burst stimulation (TBS) study, adults with ND (N = 31; female: n = 15) completed a baseline session and were then randomized to two counterbalanced sessions of functionally neuronavigated TBS to the rIFG: continuous TBS (cTBS) on 1 day and intermittent TBS (iTBS) on another. Differences in cigarette cravings, smoking, and fronto-striatal-limbic rsFC were assessed.ResultsRelative to baseline, cTBS significantly reduced appetitive and withdrawal cravings immediately after treatment. The effects of cTBS on withdrawal craving persisted for 24 h, as well as produced a reduction in smoking. Furthermore, cTBS significantly strengthened rsFC between the rIFG pars opercularis and subcallosal cingulate (fronto-striatal circuit), and between the rIFG pars opercularis and the right posterior parahippocampal gyrus (fronto-limbic circuit). At post-24 h, cTBS-induced increase in fronto-striatal rsFC was significantly associated with less appetitive craving, while the increase in fronto-limbic rsFC was significantly associated with less withdrawal craving and smoking.DiscussionThese findings warrant further investigation into the potential value of rIFG cTBS to attenuate smoking behavior among individuals with ND.

【 授权许可】

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Copyright © 2023 Upton, Brown, Golzy, Garland and Froeliger.