5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal

Journal of Pharmacological Sciences

Mitsuhiro Yoshioka²  Yu Ohmura¹  Emily M. Jutkiewicz¹  Edward F. Domino¹ 

[1] Department of Pharmacology, University of Michigan, USA;Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan

关键词: addiction;    smoking;    tobacco;   

DOI  :  10.1254/jphs.11074SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(6)Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (−)-Nicotine bitartrate or equimolar sodium tartrate was infused into each rat via a s.c. osmotic minipump for 7 days. Somatic abstinence signs (teeth-chattering/chews and shakes, etc.) were counted one day after pump removal. Somatic signs were attenuated by the i.p. injection of 5-HTP, but not by NSD-1015, a centrally-acting L-aromatic amino acid decarboxylase inhibitor, indicating that 5-HTP mitigates somatic signs mainly through its conversion to 5-HT.

【 授权许可】

Unknown