Integrative modeling of hemodynamic changes and perfusion impairment in coronary microvascular disease

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Palak Chaudhry¹  Yvonne Oberholzer¹  Andrew J. deMello¹  Monika Colombo² 

[1] Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland;Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland;Department of Mechanical and Production Engineering, Aarhus University, Aarhus, Denmark;

关键词: 3D printing;    CFD analysis;    WSS;    fabrication;    local hemodynamics;    nonobstructive coronary artery disease;   

DOI  :  10.3389/fbioe.2023.1204178

 received in 2023-04-11, accepted in 2023-07-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: Coronary microvascular disease is one of the responsible factors for cardiac perfusion impairment. Due to diagnostic and treatment challenges, this pathology (characterized by alterations to microvasculature local hemodynamics) represents a significant yet unsolved clinical problem.Methods: Due to the poor understanding of the onset and progression of this disease, we propose a new and noninvasive strategy to quantify in-vivo hemodynamic changes occurring in the microvasculature. Specifically, we here present a conceptual workflow that combines both in-vitro and in-silico modelling for the analysis of the hemodynamic alterations in the microvasculature.Results: First, we demonstrate a hybrid additive manufacturing process to fabricate circular cross-section, biocompatible fluidic networks in polytetrafluoroethylene. We then use these microfluidic devices and computational fluid dynamics to simulate different degrees of perfusion impairment.Discussion: Ultimately, we show that the developed workflow defines a robust platform for the multiscale analysis of multifactorial events occurring in coronary microvascular disease.

【 授权许可】

Unknown   
Copyright © 2023 Colombo, Chaudhry, Oberholzer and deMello.

【 图 表 】

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