Relationship between lipoprotein(a) and colorectal cancer among inpatients: a retrospective study

Frontiers in Oncology

Oncology

Huijie Wang¹  Xu Cao¹  Jinli Liu¹  Ping Meng²  Huanwei Zheng²  Haiying Zuo³  Zhichao Wang³  Teng Zhang⁴ 

[1] Department of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China;Department of Gastroenterology, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China;Graduate School, Hebei North University, Zhangjiakou, China;Institute of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, China;

关键词: lipoprotein(a);    colorectal cancer;    association;    retrospective study;    case-control study;   

DOI  :  10.3389/fonc.2023.1181508

 received in 2023-03-16, accepted in 2023-04-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

The present study was to explore the association between lipoprotein(a) [Lp(a)] and colorectal cancer (CRC) among inpatients. This study included 2822 participants (393 cases vs. 2429 controls) between April 2015 and June 2022. Logistic regression models, smooth curve fitting, and sensitivity analyses were performed to investigate the relationship between Lp(a) and CRC. Compared with the lower Lp(a) quantile 1 (<79.6 mg/L), the adjusted odds ratios (ORs) in quantile 2 (79.6-145.0 mg/L), quantile 3 (146.0-299.0 mg/L), and quantile 4 (≥300.0 mg/L) were 1.41 (95% confidence interval [CI]: 0.95–2.09), 1.54 (95% CI: 1.04–2.27), 1.84 (95% CI: 1.25–2.7), respectively. A linear relationship between lipoprotein(a) and CRC was observed. The finding that Lp(a) has a positive association with CRC supports the “common soil” hypothesis of cardiovascular disease (CVD) and CRC.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Zheng, Meng, Cao, Liu, Zhang, Zuo and Wang