Metformin inhibits spontaneous excitatory postsynaptic currents in spinal dorsal cord neurons from paclitaxel-treated rats

Frontiers in Synaptic Neuroscience

Neuroscience

Chun-Yu Qiu¹  Ting-Ting Liu¹  Wang-Ping Hu² 

[1] School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, China;School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, China;Department of Physiology, Hubei College of Chinese Medicine, Jingzhou, Hubei, China;

关键词: metformin;    paclitaxel;    sEPSCs;    nociception;    CIPN;   

DOI  :  10.3389/fnsyn.2023.1191383

 received in 2023-03-22, accepted in 2023-04-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionCancer patients treated with paclitaxel often develop chemotherapy-induced peripheral neuropathy, which has not been effectively treated with drugs. The anti-diabetic drug metformin is effective in the treatment of neuropathic pain. The aim of this study was to elucidate effect of metformin on paclitaxel-induced neuropathic pain and spinal synaptic transmission.MethodsElectrophysiological experiments on rat spinal slices were performed in vitro and mechanical allodynia quantified in vitro.ResultsThe present data demonstrated that intraperitoneal injection of paclitaxel produced mechanical allodynia and potentiated spinal synaptic transmission. Intrathecal injection of metformin significantly reversed the established mechanical allodynia induced by paclitaxel in rats. Either spinal or systemic administration of metformin significantly inhibited the increased frequency of spontaneous excitatory postsynaptic currents (sEPSCs) in spinal dorsal horn neurons from paclitaxel-treated rats. We found that 1 h incubation of metformin also reduced the frequency rather than the amplitude of sEPSCs in the spinal slices from paclitaxel-treated rats.DiscussionThese results suggested that metformin was able to depress the potentiated spinal synaptic transmission, which may contribute to alleviating the paclitaxel-induced neuropathic pain.

【 授权许可】

Unknown   
Copyright © 2023 Liu, Qiu and Hu.