Review of acute kidney injury and progression to chronic kidney disease in pediatric patients undergoing hematopoietic cell transplant

Frontiers in Oncology

Oncology

Catherine Joseph¹  Joseph R. Angelo¹  Kim T. Vuong¹ 

[1] Division of Pediatric Nephrology, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, United States;

关键词: hematopoietic cell transplant;    chronic kidney disease;    kidney injury;    kidney transplant;    nephrology;   

DOI  :  10.3389/fonc.2023.1161709

 received in 2023-02-08, accepted in 2023-04-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

While acute kidney injury (AKI) after hematopoietic cell transplant (HCT) has been well-described in pediatric patients, literature regarding the long term renal consequences of HCT-related AKI, the development of chronic kidney disease (CKD), and CKD care in pediatric patients post-HCT is limited. CKD affects almost 50% of patients after HCT with multifactorial etiology including infection, nephrotoxic medications, transplant-associated thrombotic microangiopathy, graft-versus-host disease, and sinusoidal obstruction syndrome. As renal function declines in CKD, eventually progressing to end stage kidney disease (ESKD), mortality increases and is more than 80% among patients requiring dialysis. Using society guidelines and current literature, this review summarizes definitions and etiologies of and management strategies among patients with AKI and CKD post-HCT with an emphasis on albuminuria, hypertension, nutrition, metabolic acidosis, anemia, and mineral bone disease. The goal of this review is to aid early identification and intervention in patients with renal dysfunction prior to development of ESKD, and to discuss ESKD and renal transplant in these patients post-HCT.

【 授权许可】

Unknown   
Copyright © 2023 Vuong, Joseph and Angelo

【 图 表 】

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