Lactobacillus reuteri in digestive system diseases: focus on clinical trials and mechanisms

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Zhimin Xu¹  Zichen Luo²  Yizhe Ma³  Renqiang Yu⁴  Yijing Peng⁵  Yifan Jiang⁶ 

[1] College of Resources and Environment, Innovative Institute for Plant Health, Zhongkai University of Agriculture and Engineering, Guangzhou, China;Department of Neonatology, Women’s Hospital of Jiangnan University, Wuxi Maternity and Child Health Care Hospital, Wuxi, China;Department of Neonatology, Women’s Hospital of Jiangnan University, Wuxi Maternity and Child Health Care Hospital, Wuxi, China;Department of Pediatric, Jiangyin People’s Hospital of Nantong University, Wuxi, China;Department of Neonatology, Women’s Hospital of Jiangnan University, Wuxi Maternity and Child Health Care Hospital, Wuxi, China;Research Institute for Reproductive Health and Genetic Diseases, Women’s Hospital of Jiangnan University, Wuxi Maternity and Child Health Care Hospital, Wuxi, China;Department of Neonatology, Women’s Hospital of Jiangnan University, Wuxi Maternity and Child Health Care Hospital, Wuxi, China;Wuxi Children’s Hospital, Children’s Hospital of Jiangnan University, Wuxi, China;School of Medicine, Nantong University, Nantong, China;

关键词: Lactobacillus reuteri;    gut microbiota;    infantile colic;    diarrhea;    constipation;    functional abdominal pain;    inflammatory bowel disease;    colorectal cancer;   

DOI  :  10.3389/fcimb.2023.1254198

 received in 2023-07-06, accepted in 2023-08-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesDigestive system diseases have evolved into a growing global burden without sufficient therapeutic measures. Lactobacillus reuteri (L. reuteri) is considered as a new potential economical therapy for its probiotic effects in the gastrointestinal system. We have provided an overview of the researches supporting various L. reuteri strains’ application in treating common digestive system diseases, including infantile colic, diarrhea, constipation, functional abdominal pain, Helicobacter pylori infection, inflammatory bowel disease, diverticulitis, colorectal cancer and liver diseases.MethodsThe summarized literature in this review was derived from databases including PubMed, Web of Science, and Google Scholar.ResultsThe therapeutic effects of L. reuteri in digestive system diseases may depend on various direct and indirect mechanisms, including metabolite production as well as modulation of the intestinal microbiome, preservation of the gut barrier function, and regulation of the host immune system. These actions are largely strain-specific and depend on the activation or inhibition of various certain signal pathways. It is well evidenced that L. reuteri can be effective both as a prophylactic measure and as a preferred therapy for infantile colic, and it can also be recommended as an adjuvant strategy to diarrhea, constipation, Helicobacter pylori infection in therapeutic settings. While preclinical studies have shown the probiotic potential of L. reuteri in the management of functional abdominal pain, inflammatory bowel disease, diverticulitis, colorectal cancer and liver diseases, its application in these disease settings still needs further study.ConclusionThis review focuses on the probiotic effects of L. reuteri on gut homeostasis via certain signaling pathways, and emphasizes the importance of these probiotics as a prospective treatment against several digestive system diseases.

【 授权许可】

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Copyright © 2023 Peng, Ma, Luo, Jiang, Xu and Yu